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The more defensible framing is that BED involves altered integration of these signals within reward and control circuits, rather than a clean deficiency of one hormonewhich again cautions against assuming that boosting one axis will resolve the disorder

Cannarella R, La Vignera S, Condorelli RA, Mongioi LM, Calogero AE

Some are used clinically under supervision for diagnostic or therapeutic applications, and others are frequently used off-label